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NAD+ Nasal Spray: What Is It and Why Is It Used?

Nad nasal spray is a spray form of the popular anti-aging vitamin NAD+.  Users may experience enhanced mental function, neurological improvements, DNA repair, and reduced neurodegenerative disorder symptoms​​. It’s also suggested to combat aging signs like memory loss, reduced focus, weight gain, and low energy​​. 

Specific groups, including stroke survivors, individuals with Type-2 diabetes, neurodegenerative disorders, substance abuse issues, or brain injuries, might benefit more. Additional advantages might include improved memory, focus, mood, reduced anxiety, and better metabolic health​​. 


What Is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in all living cells. It’s crucial for several biological processes, including energy metabolism, maintaining cell health, and regulating the body’s internal clock. 

Specifically, NAD+ is involved in redox reactions, transferring electrons from one reaction to another, which are fundamental for the production of energy within cells. 

Additionally, it plays a role in the repair of damaged DNA and the functioning of sirtuins, proteins important for aging and longevity. NAD+ levels naturally decrease with age, leading to research into how replenishing it can impact health and aging.

A picture of a stick figure asking if NAD nasal spray is right for him, while next to a bottle of NAD nasal spray

How Can NAD Nasal Sprays Help Me?

An NAD+ nasal spray represents a novel method of delivering NAD+ directly to the body. Here’s how an NAD+ nasal spray could potentially help someone, based on the known functions of NAD+:

Increased Bioavailability: One of the primary benefits of a nasal spray is the potential for increased bioavailability. The nasal mucosa allows for direct entry into the bloodstream, bypassing the digestive system that can alter or degrade a substance, thus potentially providing a quicker and more efficient delivery method for NAD+.

Cellular Energy Production: NAD+ is crucial for the mitochondrial function, the powerhouse of the cell, where it facilitates the production of ATP (adenosine triphosphate), the primary energy currency of the cell. By increasing NAD+ levels, a nasal spray could potentially boost energy levels and improve cellular functions throughout the body.

Supporting Sirtuins: NAD+ is essential for the activation of sirtuins, a group of proteins associated with aging. Sirtuins regulate various metabolic processes, including those related to stress responses, inflammation, and longevity. Enhanced sirtuin activity is linked to improved healthspan and lifespan in various organisms.

DNA Repair: NAD+ is a cofactor for enzymes involved in DNA repair, such as PARPs (Poly(ADP-ribose) polymerases). Maintaining adequate NAD+ levels can ensure optimal DNA repair processes, which are crucial for preventing mutations that can lead to diseases, including cancer.

Neuroprotection: There is evidence to suggest that NAD+ has neuroprotective effects.f By increasing NAD+ levels, the nasal spray may help support brain health, potentially improving cognitive function, and providing protection against neurodegenerative diseases.

Aging and Age-Related Diseases: Since NAD+ levels decline with age, and this decline is associated with various age-related diseases (including cardiovascular diseases), maintaining NAD+ levels through supplementation could potentially slow certain aspects of the aging process and decrease the risk of age-associated pathologies.

Reducing Oxidative Stress and Inflammation: NAD+ has been shown to play a role in reducing oxidative stress and inflammation, both of which are key players in the progression of many diseases.

Nad Nasal Spray Vs NAD Injections

Are NAD Nasal Sprays More Effective Than Injections?

The effectiveness of NAD+ delivery methods, such as nasal sprays versus injections, can vary based on several factors, including absorption, bioavailability, convenience, patient compliance, and potential side effects. 


NAD+ Nasal Sprays:


Absorption: Nasal sprays might provide direct and quick absorption into the bloodstream through the nasal mucosa, bypassing the digestive system and potential breakdown in the liver (first-pass metabolism).

Convenience and Compliance: Nasal sprays can be administered easily and comfortably, making them more convenient for regular use. This convenience might lead to better patient compliance with dosage schedules.

Continuous Use: Nasal sprays could potentially be used multiple times throughout the day, providing a more steady supply of NAD+ compared to injections.


NAD+ Injections:



Injections (usually intravenous) typically offer high bioavailability because they deliver substances directly into the bloodstream, ensuring that more of the active substance reaches its target.


Immediate Boost

Injections can provide an immediate boost of NAD+ levels in the body, which might be beneficial for individuals with significantly depleted levels.


Medical Supervision:

Injections often require administration by healthcare professionals, ensuring proper dosage and monitoring for side effects. However, this might be less convenient and more invasive for patients.


Side Effects and Safety:

The safety profile of NAD+ supplementation methods needs to be considered. Injections, being more invasive, might have a higher risk of side effects, including infection at the injection site or systemic reactions.


Nasal sprays might be associated with local irritation or allergic reactions but generally have a lower risk for serious complications.


Efficacy in Specific Conditions:

The effectiveness of each method might also depend on the individual’s conditions or the specific outcomes being targeted (e.g., energy restoration, cognitive improvement, or chronic illness management).

In conclusion, while nasal sprays offer ease of use and the potential for good absorption, injections might provide a more immediate and controlled dosage with high bioavailability.


Do You Need A Prescription for NAD+ Nasal Spray?

Yes, you do typically need a prescription for NAD+ nasal spray. NAD+ (Nicotinamide Adenine Dinucleotide) is a molecule that plays a crucial role in various cellular processes, and its use as a supplement is subject to regulations in many countries. To obtain NAD+ nasal spray, you would generally require a prescription from a qualified healthcare provider. Here’s why:

Medical Supervision: NAD+ supplements, especially in higher doses, can have potential side effects and interact with other medications or medical conditions. Therefore, it’s important to have a healthcare professional assess your specific health situation and determine if NAD+ nasal spray is appropriate for you.

Legal and Regulatory Requirements: In many regions, NAD+ is classified as a medication or dietary supplement, and its distribution is regulated by government agencies. Obtaining a prescription helps ensure that the product is used safely and in compliance with applicable laws.

To acquire a prescription for NAD+ nasal spray, you can set up a telehealth meeting with Weight Wise today! Simply click here to call or here to submit a consultation form!


What Are The Side Effects Of Nicotinamide?

NAD+ (Nicotinamide Adenine Dinucleotide) supplementation is generally considered safe when used appropriately. However, like all supplements or treatments, it can potentially cause side effects, especially when taken in high doses, or via more direct administration routes like injections. Below are some potential side effects associated with NAD+ supplementation:


  • Fatigue: Some people might experience fatigue or lethargy, especially soon after starting NAD+ therapy.
  • Nausea, Upset Stomach, and Other Digestive Issues: Oral supplementation or infusions can sometimes upset the digestive system, leading to symptoms like nausea, indigestion, or diarrhea.
  • Flushing: Nicotinamide, a form of vitamin B3 used in some NAD+ supplements, can cause flushing, a sensation of warmth, itching, redness, or tingling in the face, arms, or chest.
  • Headache: Headaches are a potential side effect, particularly following high-dose infusions.
  • Dizziness or Lightheadedness: Some individuals might experience dizziness or lightheadedness as a response to changes in blood pressure.
  • Complications at Injection Site: If NAD+ is administered through an IV, there might be complications at the injection site, such as irritation, pain, or infection.
  • Hypersensitivity Reactions: Allergic reactions or hypersensitivity to the components of the NAD+ formulation can occur.
  • Low Blood Pressure: There have been instances where high-dose NAD+ infusions have caused a temporary drop in blood pressure.
  • Rapid Heart Rate: Some people might experience an increase in heart rate during or after NAD+ administration, particularly with intravenous infusions.



NAD+ nasal spray is gaining popularity as a novel method for delivering this essential coenzyme, known for its potential benefits in various aspects of health, including enhanced energy metabolism, DNA repair, and neuroprotection. It may particularly benefit individuals with specific health conditions or those looking to combat signs of aging. 


While NAD+ supplementation holds promise, including through nasal sprays, its effectiveness compared to other delivery methods like injections depends on factors such as bioavailability, convenience, and individual health goals. Regardless of the administration route, consulting with healthcare professionals is crucial to ensure safe and appropriate usage of NAD+ supplements, as they may cause side effects in some individuals, especially when taken in high doses or through direct injection.

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