NAD+ (nicotinamide adenine dinucleotide) injections are gaining traction in the world of weight loss and wellness for their ability to boost cellular energy, improve metabolism, and support overall health. At Weight Wise Weight Loss Center, we offer medically supervised NAD+ injection programs to help you achieve optimal results. But a common question we get from clients is: Should I get NAD+ subcutaneously or intramuscularly? Understanding the differences, benefits, and drawbacks of each method is key to choosing the right option for your body and goals.
Understanding NAD+
NAD+ is a coenzyme found in all living cells and plays a vital role in energy production, DNA repair, and cellular health. As we age or experience metabolic stress, NAD+ levels decline. This leads to fatigue, slower metabolism, weight gain, brain fog, and even premature aging. Supplementing with NAD+ through injections helps restore those levels and support your weight loss journey from the inside out.
The Pros of Subcutaneous NAD+ Injections
Subcutaneous (SQ) injections are administered just beneath the skin, usually in the abdomen or upper thigh. One of the major advantages of this method is ease and comfort. The smaller needle and shallow injection site make it virtually painless for most clients, making this an excellent option for those new to injections or with needle sensitivity.
Another benefit of subcutaneous NAD+ injections is their slow-release absorption. Because the NAD+ is absorbed gradually through the fatty layer under the skin, clients often report a more sustained energy boost throughout the day. This can be ideal for maintaining consistent energy levels during long work hours, workouts, or fasting protocols.
SQ injections are also suitable for self-administration at home. Many of our clients at Weight Wise appreciate the convenience of receiving their injections without needing to visit the clinic each time. With proper training from our medical team, you can confidently integrate this therapy into your daily routine.
The Cons of Subcutaneous NAD+ Injections
Despite the many benefits, subcutaneous injections may not be the best fit for everyone. One of the drawbacks is the slower onset of effects. Because the absorption is more gradual, it might take longer for you to notice improvements in energy, focus, or metabolic function.
Additionally, not everyone responds equally to the SQ method. Some clients may require larger or more frequent doses to reach therapeutic levels, particularly if they have significant metabolic stress or are recovering from chronic fatigue or inflammation.
Lastly, some individuals may experience mild irritation or swelling at the injection site, although these side effects are typically minimal and resolve quickly. For more information on side effects check out this article by Weight Wise.
The Pros of Intramuscular NAD+ Injections
Intramuscular (IM) injections are delivered deep into the muscle, usually in the deltoid (shoulder) or gluteal area. This method allows for faster absorption and a more immediate energy boost, which is a major advantage for individuals who are dealing with severe fatigue, burnout, or brain fog.
IM injections are also highly bioavailable, meaning more of the NAD+ enters your system rapidly and efficiently. This can translate into quicker improvements in mental clarity, physical performance, and metabolic function—a great choice for those who want results fast.
At Weight Wise, our trained professionals carefully administer IM injections in a comfortable, clinical setting to ensure safety and effectiveness. Many clients opt for this method weekly or biweekly as part of their weight loss and rejuvenation protocol.
The Cons of Intramuscular NAD+ Injections
One of the main drawbacks of IM injections is discomfort. The injection goes into deeper tissue, which can sometimes lead to soreness, bruising, or muscle tightness at the site.
Because the IM method delivers a large amount of NAD+ quickly, some clients may experience a brief “flush” or light-headedness post-injection. While rare, these effects typically subside within minutes.
Another consideration is that IM injections require professional administration. This means regular clinic visits, which may be less convenient for individuals with tight schedules or limited mobility.
NAD+ Subcutaneous vs. Intramuscular Comparison Chart
| Feature | Subcutaneous (SQ) Injection | Intramuscular (IM) Injection |
| Absorption Speed | Slower, sustained release | Faster, immediate release |
| Comfort Level | Less painful, smaller needle | More discomfort, larger needle |
| Onset of Effects | Gradual (good for sustained energy) | Rapid (good for quick boosts) |
| Best For | Daily wellness, steady support | Fatigue recovery, performance support |
| Self-Administration | Yes, after medical training | No, must be done at the clinic |
| Side Effects | Mild swelling, irritation | Soreness, lightheadedness possible |
| Convenience | Home-friendly, flexible dosing | Requires regular clinic visits |
| Bioavailability | Moderate | High |
Are NAD+ Injections Right for You?
If you’re feeling depleted, struggling to lose weight, or looking to improve your cellular health from the ground up, NAD+ therapy may be a perfect fit. Whether you choose subcutaneous or intramuscular administration depends on your goals, lifestyle, and how your body responds to the treatment.
At Weight Wise, our expert team will guide you through the process and tailor your NAD+ injection plan to your unique needs. Whether you want a steady boost throughout your week or a powerful surge of energy to crush a busy schedule, we have the right approach to get you there.
What to Expect at Your Weight Wise Consultation
Your journey starts with a comprehensive consultation at Weight Wise Weight Loss Center. Our medical team will review your health history, current symptoms, and weight loss goals. We’ll also help you determine whether subcutaneous or intramuscular NAD+ injections are the best fit.
If you’re new to injections, we’ll walk you through every step—from technique and dosing to proper hygiene and safety. For clients who opt for in-clinic IM administration, we offer flexible appointment times and supportive care throughout your program.
Begin Your Transformation at Weight Wise
At Weight Wise Weight Loss Center, we’re proud to offer customized NAD+ therapy programs designed to meet you where you are and take you where you want to go. Whether you’re overcoming a plateau or just getting started, NAD+ injections can reignite your energy, help your body work more efficiently, and accelerate your progress.
Contact Weight Wise Weight Loss Center today to schedule your NAD+ consultation. Let us help you take the next step toward a healthier, more energized you.
