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How To Inject Mounjaro

Mounjaro, or tirzepatide, is a prescription medication that has been used to treat type 2 diabetes and most recently help with weight loss. It’s best used and most effective when done so with living a healthy lifestyle and eating healthily. 

In this article we will cover the best practices when it comes to injecting Mounjaro, as well as some common questions around the medication.

Choosing Your Injection Site

Step 1: Choosing Your Injection Site

Mounjaro can be self-injected in the thigh, abdomen, or back of the upper arm (with assistance from another person). It’s recommended to rotate the injection site each week to minimize any potential skin irritation or discomfort. 

For example, if you injected Mounjaro in your right thigh on week one, on week two you would inject your left thigh, and then week three your abdomen. While it may be acceptable to use the same general injection area, it’s best practice to choose a different site within that area.

If an injection site is bruised or irritated, it’s important to avoid using it and choose a different site to minimize the risk of further discomfort or complications.

Your healthcare provider can provide guidance on the best injection sites and techniques for administering Mounjaro safely and effectively. By rotating your injection sites and following proper injection techniques, you can ensure the best possible results while minimizing any potential discomfort or complications.

Pull Off Gray Base Cap

Step 2: Pull Off The Gray Base Cap

When using the Mounjaro injection pen, it’s important to ensure that the pen is locked before use. Only unlock the pen when you are ready to inject and have placed the clear base on your skin. 

Before use, pull the gray base cap straight off and dispose of it in your household trash. Do not attempt to put the gray base cap back on the pen, as this could damage the needle and impact the effectiveness of the injection. 

Additionally, it’s important to avoid touching the needle to minimize the risk of contamination or infection.

Place The Clear Base On Your Skin

Step 3: Place The Clear Base On Your Skin

Place the clear base on your injection site and unlock the pen by turning the locking ring.

10 Seconds

Step 4: Press and Hold For 10 Seconds 

When administering the Mounjaro injection, it’s important to press and hold the purple injection button for up to 10 seconds. As you inject, listen for two clicks: the first click indicates that the injection has started, while the second click indicates that the injection is complete. You’ll know that the injection is finished when the gray plunger is visible.

Sharps Container

Step 5: Dispose of The Pen

Proper disposal of your used Mounjaro pen is essential for the safety of both yourself and others. After use, put the used pen in an FDA-cleared sharps disposal container immediately. It’s important not to throw pens in your household trash. If you don’t have an FDA-cleared sharps disposal container, you may use a household container that is made of heavy-duty plastic, can be closed with a tight-fitting, puncture-resistant lid, is upright and stable during use, leak-resistant, and properly labeled to warn of hazardous waste inside the container.


When your sharps disposal container is almost full, it’s important to follow your community guidelines for proper disposal. State or local laws may also dictate how used needles and syringes should be thrown away. For more information about safe sharps disposal and specific information about sharps disposal in your state, visit the FDA’s website at https://www.fda.gov/safesharpsdisposal.


Remember, do not recycle your used sharps disposal container. By following these guidelines, you can ensure the safe and effective use of your Mounjaro injection therapy, and protect yourself and others from potential harm.

Frequently Asked Questions

Where Is The Best Place to Inject Mounjaro?

There is no “best” place to inject Mounjaro. Mounjaro can be injected into the thigh, abdomen, or back of the upper arm (with help from another person). It is recommended to rotate injection sites each week, meaning that if you injected MOUNJARO in your right thigh on week one, on week two you would inject your left thigh, and then week three your abdomen. 

Under some circumstances, it may be okay to use the same injection area, but it is best practice to choose a different site within that area. If an injection area is bruised or irritated, it should not be used.


What Is The Best Time To Inject Mounjaro?

When it comes to injecting mounjaro , there is no specific “best” time to take it. What’s important is that you take it at the same time each week to ensure consistent blood sugar control and weight loss. 

Choose a time that works best for your schedule and try to stick to that time every week. This could be in the morning, afternoon, or evening, depending on your preferences and lifestyle. 

Your healthcare provider can provide guidance on the best time for you to take mounjaro based on your individual needs and circumstances.


How Should I Inject Mounjaro For Weight Loss?

Mounjaro can be injected subcutaneously, which means beneath the skin, in the thigh, abdomen, or back of the upper arm. 

There is no “best” way to inject Mounjaro for weight loss, and it ultimately depends on what is most comfortable and convenient for you.

 The most important thing is to ensure that the medication is injected subcutaneously and that you follow the proper injection technique. Your healthcare provider can give you guidance on proper injection technique and help you choose the injection site that works best for you.

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